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The 5 Best Gluten-Free American Restaurants in Downtown Des Moines

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By Gluten Free Eats' gluten-free community

Updated Apr 2025

01
Americana

Americana

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Celiac friendly

1312 Locust St, Des Moines, IA 50309, USA

AmericanBrunchGF OptionsAllergen FriendlyBreakfastDairy Free OptionsDeliveryDinnerOpen Late NightLunchTake AwayVegan OptionsVegetarian OptionsDedicated GF FryerCiderDessertsCeliac FriendlyKnowledgeable StaffKid FriendlyPancakesBread ItemsSandwichesCocktails
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Jennifer VanSickle

Love it every time. Good atmosphere and I'm pretty find if the gluten sensitive choices. Well worth it.

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Gluten-free options are marked
02
Buzzard Billy’s

Buzzard Billy’s

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Accommodating

615 3rd St, Des Moines, IA 50309, USA

AmericanGF OptionsDinnerKid FriendlyOpen Late NightLunchTake AwayBread ItemsCiderBreakfastBrunchDeliveryOutdoor SeatingRestaurant
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Cheyenne Schnathorst

One of the biggest Gluten Free menus I've seen! Thanks for offering this, those who can't eat gluten don't usually get so many delicious options. Mardi Gras Alfredo was excellent! Our waiter was also great!

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Dedicated gluten-free menu
03
Tupelo Honey Southern Kitchen & Bar

Tupelo Honey Southern Kitchen & Bar

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Gluten-free options

665 Grand Ave Ste 100, Des Moines, IA 50309, USA

BreakfastLunchDinnerBrunchAmericanDeliveryTake AwayPet FriendlyOutdoor SeatingKid Friendly
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Jennifer Bartlett

Shrimp and grits, collard greens with bacon...I felt like I was back home. The gluten free options are limited, but they are done well!

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04
Bubba

Bubba

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Gluten-free options

200 10th St, Des Moines, IA 50309, USA

LunchDinnerBrunchAmericanDeliveryTake AwayOutdoor SeatingKid FriendlyRestaurant
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Ben Miller

Went in on a quiet Thursday afternoon and the service and food were top shelf. Ribeye steak was cooked to perfection. Brussels were excellent and the cornbread is actually GLUTEN FREE! Start with the deviled eggs or the street corn dip!

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05
RoCA

RoCA

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Gluten-free options

208 Court Ave, Des Moines, IA 50309, USA

LunchDinnerOpen LateAmericanCocktailsDeliveryTake AwayBarRestaurant
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Brian Moe

Delicious food options. Had the gluten free steak and mushroom flatbread. It was hold-your-breath-and-close-your-eyes delicious. Brussel sprouts were on point. Deconstructed nachos were amazing. And service was excellent, especially given the unexpected rush at the end of the night.

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